A heavy way that, as typically used, goes against the grain of the web, particularly for document-centric sites. For example, on the Oxide RFD site, the RFD links don't do a real browser page load, but use JavaScript to fetch the new content and update the page in-place. This breaks the experience of screen-reader users unless the site or framework does some kind of workaround (which, somewhat to my surprise, the Oxide RFD site doesn't do), and even then, it doesn't match the experience of doing a real transition between pages with a screen reader. For something like the Oxide RFD site, I'd be much more inclined to use something like Astro or Marko, with minimal client-side JavaScript and no SPA-style navigation.
